Answer to discussion kemi

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Clotrimazole’s medicinal effects (Lotrimin)

Clotrimazole functions by penetrating the fungus’ cytoplasmic membrane. Clotrimazole inhibits the demethylation of 14 alpha lanosterol, preventing the production of ergosterol. Also, clotrimazole is an antifungal medication and decreases the membrane’s permeability in fungi. This exercise explains clotrimazole’s indications and side effects (Sheth & Dande, 2021). Clotrimazole is an antifungal medicine applied topically to the affected area to treat fungal infections of the skin. This drug is available without a prescription. Triclocarban is the generic name for clotrimazole, and It inhibits fungal development. Inhibiting the production of the membrane that envelops fungal cells slows fungal growth. It can be applied to the affected area, taken orally, or dissolved in the mouth to treat localized fungal infections.

Clotrimazole alleviates irritation, itch, and discharge, and the antifungal azole defends against yeast infections. It heals yeast infections and athlete’s foot due to its metabolic profile and low risk of side effects. All of these properties facilitated the treatment of a wide variety of diseases. Blood and body levels of clotrimazole are low after topical or vaginal absorption (Zhang & Michniak-Kohn 2018). Clotrimazole is effective against yeast fungus, and the infection must be treated for two weeks to prevent a recurrence. Generally, thrush can be cured within a week, while optimal treatment lasts two weeks. Itching or burning is the side effect that occurs most frequently. In addition to being antifungal, clotrimazole has pharmacological characteristics. These effects are the result of ergosterol production inhibition. Unrelated side effects of Clotrimazole on multiple cell targets.

 

 

Describe antifungal drug uses and side effects

Side effects

Fungi can induce symptoms that disappear within a few weeks. Antifungal resistance can develop when antifungals are taken for a longer length of time or when treatment is insufficient(Benitez & Carver, 2019). Fungi are capable of causing fungal infections. These are capable of infecting animals, objects, and dirty surfaces. An excess of yeast can cause thrush. Fungi infections can be treated with antifungal drugs that do not affect human cells (Nicola et al., 2019). Redness, inflammation, or irritation define this rash hence adverse effects. Antifungal drugs rarely cause liver damage. Typical signs of anaphylaxis and other potentially lethal allergic reactions are bleeding and peeling of the affected area.

Antifungal drugs use 

Antifungal medicines are used to treat fungal infections. Oral, topical, and injectable formulations of antifungal drugs are available. Antifungal medication is used to treat fungal infections. Also, Antifungals are used to treat skin, lung, nail, and other organ fungal infections. Meningitis and pneumonia are fungal infections. Fungi produce enzymes, organic acids, vitamins, and antibiotics employed in food and business. Antibiotics have progressed more rapidly than antifungals. Given the cellular nature of the animals, this is understandable. Prokaryotic bacteria offer diverse structural and metabolic objectives compared to their human hosts. As eukaryotes, fungi are detrimental to their hosts. The sluggish and multicellular proliferation of fungi makes them more challenging to quantify than bacteria. This makes in vitro and in vivo testing of antifungal drugs difficult.

 

Create a lesson plan for Ms Jones that considers Sam’s age.

Ms Jones’ lesson plan must incorporate dosing, dose levels, following the doctor’s recommendations, and general pharmacological ideas. she shall follow your instructions precisely. She is always taking your prescription daily at the same time (use a memory aid such as bedtime, charts, or pillboxes). She should teach not to skip doses or take the drug in lower quantities to save money. Continue taking the medication as prescribed until the bottle is empty unless your doctor directs you otherwise. Do not take a drug prescribed for another individual. In addition, she should recommend that he visit his physician before terminating the prescription he is now taking. It is imperative to take the medication till the expiration date has gone. She also avoids delivering doses that are either excessively high or insufficient due to the possibility of unwanted side effects.

 

 

 

 

 

 

 

 

 

 

 

 

 


References


Benitez, L. L., & Carver, P. L. (2019). Adverse effects associated with long-term administration of azole antifungal agents. Drugs79(8), 833-853.
https://link.springer.com/article/10.1007/s40265-019-01127-8 (Links to an external site.)

Nicola, A. M., Albuquerque, P., Paes, H. C., Fernandes, L., Costa, F. F., Kioshima, E. S., … & Felipe, M. S. (2019). Antifungal drugs: New insights in research & development. Pharmacology & therapeutics195, 21-38.
https://www.sciencedirect.com/science/article/pii/S016372581830192X (Links to an external site.)

Sheth, U., & Dande, P. (2021). Pityriasis capitis: Causes, pathophysiology, current modalities, and future approach. Journal of Cosmetic Dermatology20(1), 35-47.
https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.13488?casa_token=ORwvNIS71f8AAAAA:sgMuwuUMrUKJhoJgcG1Io1vHUeubmoEiiVmts8HS063-DVk7AviZ9OxhhUN8Owd0zyh4cpp0d8P_sbla (Links to an external site.)

Zhang, J., & Michniak-Kohn, B. B. (2018). Investigation of microemulsion and microemulsion gel formulations for dermal delivery of clotrimazole. International journal of pharmaceutics536(1), 345-352.
https://www.sciencedirect.com/science/article/pii/S0378517317310918

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